Advances of Long Non-Coding RNAs as Potential Biomarkers for Tuberculosis: New Hope for Diagnosis?
نویسندگان
چکیده
Tuberculosis (TB), one of the top ten causes death globally induced by infection Mycobacterium tuberculosis (Mtb), remains a grave public health issue worldwide. With almost one-third world’s population getting infected Mtb, between 5% and 10% these individuals are predicted to develop active TB disease, which would not only result in severe tissue damage necrosis, but also pose serious threats human life. However, exact molecular mechanisms underlying pathogenesis immunology remain unclear, significantly restricts effective control epidemics. Despite significant advances current detection technologies treatments for TB, there still no appropriate solutions that suitable simultaneous, early, rapid, accurate screening TB. Various cellular events can perturb development progression always associated with several specific signaling controlled dysregulated gene expression patterns. Long non-coding RNAs (lncRNAs), kind RNA (ncRNA) transcript more than 200 nucleotides length eukaryotic cells, have been found regulate protein-coding genes involved some critical events, such as inflammatory, pathological, immunological responses. Increasing evidence has claimed lncRNAs might directly influence susceptibility well Therefore, widely expected serve promising biomarkers therapeutic targets In this review, we summarized functions their regulatory roles More importantly, discussed potential act biomarkers, offer new possibilities novel diagnostic strategy exploration benefit epidemic.
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2023
ISSN: ['1999-4923']
DOI: https://doi.org/10.3390/pharmaceutics15082096